Zyprexa and Diabetes

Zyprexa and Diabetes

Diabetes Mellitus
Diabetes Ketoacidosis
Diabetic Coma
Diabetic Hyperosmolar Syndrome

The unfortunate nature of the "atypical" antipsychotic drug Zyprexa is that it disrupts the body's natural sensitivity to insulin, resulting in a condition called diabetes mellitus type II. Insulin is a naturally occurring hormone secreted by the pancreas that regulates the metabolism of carbohydrates, fats and proteins. Insulin is the means by which energy is extracted from glucose by cells to use for fuel. Zyprexa decreases the insulin sensitivity of the body, which raises the amount of sugar in the bloodstream – a condition known as hyperglycemia. With this excess sugar and no hormone to process it, the body begins to go into toxic shock, affecting the cardiovascular, renal, and metabolic systems. This side effect has caused the Food and Drug Administration to require that all atypical antipsychotics such as Zyprexa display warning labels to notify users that these drugs have the potential to cause serious metabolic side effects including diabetes.

Since Zyprexa disturbs the delicate metabolism and insulin balance, several different types of diabetic side effects can occur. These include diabetes Mellitus, diabetes ketoacidosis, diabetic coma, and diabetic hyperosmolar syndrome.

Diabetes Mellitus

Diabetes mellitus is a serious medical condition that results from an elevated level of blood sugar, called glucose. Glucose is the primary form of energy used by our cells to power the body. It is the job of the hormone insulin to facilitate the transfer of glucose into the cells of the body. Zyprexa decreases the sensitivity of cells to insulin, which increases the amount of sugar in the bloodstream. When insulin sensitivity is disrupted by the introduction of an outside influence such as Zyprexa, the excess blood sugar causes drastic and immediate reactions within the body. Diabetes mellitus is often a side effect of Zyprexa and if left unchecked can lead to blindness, renal damage, cardiovascular failure and even death.

In a disturbing report on the correlation of Zyprexa and diabetes mellitus, 7 out of 19 patients developed hyperglycemia, one of the initial stages of diabetes mellitus. Of those first seven, two developed the condition within a week, and another eight were stricken within six months. Sadly, one of the patients developed pancreatitis, and eventually died. Despite the incredible risks the Food and Drug Administration allowed Zyprexa to enter the market in 1996. Since then it has become one of the most popular and lucrative antipsychotic drugs, with annual sales totaling 4.3 billion dollars.

If you developed diabetes mellitus while taking Zyprexa to combat schizophrenia or bipolar disorders, then you deserve to be compensated the unintended consequences. Don't hesitate, because the law has time limits on how long you have to collect damages.

Diabetes Ketoacidosis

Diabetes Ketoacidosis results from a chain reaction caused by a disruption of the body's insulin/glucose balance, which is a common side effect of Zyprexa, occurring when Diabetes Mellitus runs unchecked and out of control. If the body cannot draw energy out of blood sugar (glucose), internal metabolism searches for a new source of fuel. Some acids in the body can be converted directly into energy, but there are a finite amount of those acids, and eventually they will be consumed. The body will then begin to convert fat cells into energy, but because the brain cannot use fat cells for energy, muscle tissue is dissolved to provide the vital energy needed to keep the brain working. As fat cells are depleted the body appears emaciated, starved of its own tissues.

The liver then releases chemicals into the blood stream to power the brain, but such a drastic increase of these chemicals increases acidity. This acid combined with an overworked liver and too much glucose triggers an increase in kidney filtration. They attempt to filter out the excess chemicals in the bloodstream, which increases urination, resulting in dehydration. Dehydration exacerbates ketoacidoisis and begins a downward spiral of worsening health. As more fluid is lost from the body the condition worsens into a coma and eventual death.

Zyprexa is a potential cause of diminishing insulin sensitivity, which eventually leads to hyperglycemia. Because most patients are unaware of this possible condition, it is common for unchecked hyperglycemia to lead to diabetes mellitus. Although hyperglycemia is easily manageable, those at risk of diabetes need to be advised of potential risks. Early studies show that Eli Lilly may have been aware of certain potential risks, but chose to ignore or deflate the importance of the red flags and continue on with marketing the drug as an effective treatment for many neurological disorders.

Diabetic Coma

A diabetic coma is a truly life-threatening condition. Diabetic ketoacidosis or hyperosmoslar syndrome cause a cascade of events that if left unchecked, will result in a diabetic coma and eventual death. The cycle begins when a victim has too much or too little blood sugar (glucose) and too little insulin to process it. As the condition worsens, the body begins to dehydrate and lose fluid rapidly as the kidneys attempt to rid the body of excess glucose by dumping it directly into urine. The process accelerates to the point where the brain no longer functions - starved of fuel - and the victim lapses into a coma.

Depending on the nature of the diabetes that caused the coma, treatment options are limited. Regardless of the cause, a diabetic coma is an immediately life-threatening condition which calls for prompt medical attention. If allowed to progress, the coma victim will die in short order. Zyprexa has the potential to lead to a diabetic coma due to the tendency of drug to reduce insulin sensitivity in the patient without their knowledge. Without proper recognition of the symptoms, victims unaware of their condition will commonly assume they are suffering from the flu or other similar illness. This dangerous ignorance often leads to hyperglycemia, which causes ketoacidosis or hyperosmoslar syndrome, which both can result in a coma and eventual death.

A lack of full side effect warnings can lead to unnecessary suffering for Zyprexa customers, which can result in serious conditions and even death. If you have been a victim of a diabetic coma because of Zyprexa, you have a right to seek restitution for your pain and suffering. Don't hesitate, for state law limits how much time you have to collect damages.

Diabetic Hyperosmolar Syndrome

Diabetic Hyperosmolar Syndrome shares many similar characteristics with diabetic ketoacidosis, but differs in cause and treatment. Elevated blood sugar levels force more water out of the cells and into the blood stream through the process of osmosis. The nature of increased sugar in the blood dehydrates the tissues it comes in contact with. This increases the amount of fluid in the bloodstream, which forces the kidneys to filter unprocessed glucose by dumping it directly into urine. Increased kidney output results in decreased hydration levels which combined with circulatory dehydration eventually causes the blood to become thick and syrupy. Also, increased kidney output decreases the body's concentration of electrolytes, which further lowers the health of the patient. This combination of factors causes a coma similar to that of diabetic ketoacidosis, and requires immediate medical treatment.

Hyperosmolar Syndrome is especially dangerous because it shares common symptoms with much more benign conditions, such as the flu. Since most people who take Zyprexa are unaware that there are significant risks of diabetic side effects, lack of warning and rapid onset of the syndrome pose immediate and serious health risks. The Food and Drug Administration mandated that all atypical antipsychotics like Zyprexa carry warnings regarding serious diabetic consequences, but most patients are unaware of the risk until they succumb to a diabetic episode.

Zyprexa was created with the intent of relieving debilitating neurological conditions, but caused more damage from side effects than expected. If you've been a victim of unintended side effects from the drug, your suffering deserves compensation. Don't delay though, for the law puts limits on the amount of time you have to collect damages.



       
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